Key result
Active-fixation leadless pacemaker provides chronotropic support with ~8% pacing burden in cardiac lymphoma.
Why the study?
Cardiac lymphoma can cause rapidly progressive high-grade atrioventricular block, but because conduction disease may improve with lymphoma-directed therapy, pacemaker decisions remain complex.
Case Report (n=1)
Active-fixation leadless pacemakers may be a viable option for patients with cardiac lymphoma and high-grade AV block, offering lower infection risk and retrievability if conduction improves with cancer therapy.
Answers are grounded in this paper and cite their sources.
May support leadless pacing consideration in select lymphoma-related AV block; leaves open durability, infection benefit, and generalizability.
BACKGROUND: Cardiac lymphoma can cause rapidly progressive high-grade atrioventricular block by infiltrating the conduction system. Because conduction disease may improve with lymphoma-directed therapy, pacemaker decisions are complex. CASE SUMMARY: A 44-year-old man with lymphoma developed extensive secondary cardiac involvement and progressive conduction system disease. Given the possibility of reversibility with immunotherapy, multidisciplinary discussions and shared decision-making were used to determine whether pacemaker implantation was warranted and to select the most appropriate device. An active-fixation leadless pacemaker was ultimately implanted. DISCUSSION: This case highlights the uncertainty regarding pacemaker management in cardiac lymphoma. Decisions should be individualized based on expected treatment response, infection risk, and patient preferences. TAKE-HOME MESSAGES: Cardiac lymphoma may present with rapidly progressive conduction disease, and the degree of reversibility following lymphoma-directed therapy can be difficult to predict. Decisions regarding pacemaker implantation should be individualized and informed by the expected treatment response, infectious and procedural risks, and patient preferences.
No takes yet. Share an insight, caveat, or question.
Sollee et al. (2026) conducted a case report in Secondary cardiac lymphoma with high-grade heart block (n=1). Active-fixation leadless pacemaker was evaluated. In a patient with secondary cardiac lymphoma and rapidly progressive high-grade heart block, an active-fixation leadless pacemaker provided chronotropic support with an 8% pacing burden at 1 month.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: