Key result
Pre-arrest major organ dysfunction is linked to ~7.1-fold higher mortality after postcardiac surgery arrest.
Why the study?
Despite improvements in rescue strategies, postoperative cardiac arrest in adults undergoing cardiac surgery has not been examined in the contemporary era.
What are the incidence, outcomes, and predictors of survival to hospital discharge in adult patients who suffer an in-hospital cardiac arrest after open cardiac surgery?
Cohort (n=162)
No
What are the incidence, outcomes, and predictors of survival to hospital discharge in adult patients who suffer an in-hospital cardiac arrest after open cardiac surgery?
Although postoperative cardiac arrest after open cardiac surgery is uncommon (1.6%), over one-third of patients fail to survive to discharge, with pre-arrest major organ dysfunction serving as the strongest predictor of mortality (aOR 7.08), highlighting the need for early recognition and escalation of care in deteriorating patients.
Answers are grounded in this paper and cite their sources.
May warrant heightened surveillance for pre-arrest organ dysfunction; leaves open whether targeted rescue strategies improve survival.
Objective Despite improvements in rescue strategies, postoperative cardiac arrest in adults undergoing cardiac surgery has not been examined in the contemporary era. This study assesses the incidence, outcomes, and predictors of survival in patients who suffered an in-hospital cardiac arrest after cardiac surgery. Methods Adult patients with cardiac arrest after open heart surgery from January 2012 to May 2019 at a single institution were studied. Patients were excluded if they underwent heart transplantation or LVAD implantation, experienced pre- or intra-operative cardiac arrest, received pre- or intra-operative temporary mechanical circulatory support, or were deemed do not resuscitate and/or care withdrawn prior to the arrest. Results Of 9,946 patients, 162 (1.6%) experienced a post-operative arrest with failure to rescue in 59 (36.4%) patients. The etiology of cardiac arrest was cardiovascular in 101 (62.3%), respiratory in 27 (16.7%), metabolic in 15 (9.3%), other in 12 (7.4%) and unknown in 7 (4.3%). Thirteen (8.0%) patients were placed on ECMO post-arrest with only 4 (30.8%) surviving to discharge. Patients were more likely to die in-hospital if they had post-operative, pre-arrest organ dysfunction (aOR 7.08, 95% CI: 2.92-17.16). Conclusions While the incidence of cardiac arrest was low, over one-third of patients failed to be rescued. Pre-arrest major organ dysfunction portended a significantly worse prognosis. Early recognition of a non-thriving patient and rapid escalation of specialized care may be critical in successful rescue from cardiac arrest and aborting catastrophic outcomes.
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Patel et al. (2026) conducted a cohort in In-hospital cardiac arrest after open cardiac surgery (n=162). Postoperative, pre-arrest major organ dysfunction vs. Absence of postoperative, pre-arrest major organ dysfunction was evaluated on In-hospital mortality (failure to rescue, FTR) before hospital discharge (aOR 7.08, 95% CI 2.92-17.16, p=<0.001). Postoperative pre-arrest major organ dysfunction strongly predicted in-hospital mortality (failure to rescue) after cardiac arrest following cardiac surgery (aOR 7.08, 95% CI 2.92-17.16).
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