Higher METS-IR values were significantly associated with the presence of concurrent hypertension and type 2 diabetes mellitus (OR 1.095) and demonstrated good discriminative ability for identifying metabolic syndrome.
Cross-Sectional (n=162)
No
Do insulin resistance-based indices (TyG index, TyG-BMI, TG/HDL ratio, METS-IR) correlate with clinical characteristics and metabolic abnormalities in patients with essential hypertension?
Insulin resistance-based indices, particularly METS-IR and the TyG index, can facilitate early identification of metabolic risk and improve cardiometabolic risk stratification in hypertensive patients.
Odds Ratio: 1.095 (95% CI 1.058–1.138)
p-value: p=<0.0001
Abstract Insulin resistance (IR) is a key cardiometabolic abnormality involved in the development and progression of hypertension and is closely associated with diabetes mellitus, metabolic syndrome, and cardiovascular disease. Surrogate markers derived from routinely available laboratory parameters that do not require insulin measurement are gaining increasing importance in the assessment of metabolic risk among patients with hypertension. In this retrospective study, we evaluated the associations between insulin resistance indices calculated from routine laboratory parameters (TyG index, TyG-BMI, TG/HDL ratio, and METS-IR) and clinical characteristics in patients with essential hypertension and in those with both essential hypertension and type 2 diabetes mellitus. The investigated indices differed significantly between the study groups and proved useful for identifying metabolic abnormalities. Among these markers, METS-IR demonstrated superior performance in reflecting cardiometabolic risk, whereas the simpler indices, particularly the TyG index, appear to be more suitable as screening tools. These findings suggest that insulin resistance-based indices may facilitate the early identification of metabolic risk and improve cardiometabolic risk stratification in patients with hypertension.
Aliz-Nóra et al. (Wed,) conducted a cross-sectional in Arterial hypertension and type 2 diabetes mellitus (n=162). METS-IR (Metabolic Score for Insulin Resistance) vs. Lower METS-IR values was evaluated on Concurrent hypertension and type 2 diabetes mellitus (HT+DM status) (OR 1.095, 95% CI 1.058-1.138, p=<0.0001). Higher METS-IR values were significantly associated with the presence of concurrent hypertension and type 2 diabetes mellitus (OR 1.095) and demonstrated good discriminative ability for identifying metabolic syndrome.