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The clathrin-independent carriers/glycosylphosphatidylinositol-attached protein-enriched endosomal compartments (CLIC/GEEC) pathway is a clarithin- and dynamin-independent endocytic pathway. CLIC/GEEC-mediated endocytosis is a large-capacity, rapid-acting process that is utilized by cells for bulk uptake of nutrients and membrane-anchored cargo and for homeostatic maintenance of membrane tension. Here, we present a brief overview of this pathway, including its known molecular mechanisms, inhibitors, activity in different cell types, and its potential relevance in mechanophysical DNA transfection.
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Weaver et al. (2025) studied this question.
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