What question did this study set out to answer?

The aim was to determine if lowering serum cholesterol levels with clofibrate could reduce ischaemic heart disease incidence.

October 1, 1978Heart1,058 citationsOpen Access

A co-operative trial in the primary prevention of ischaemic heart disease using clofibrate. Report from the Committee of Principal Investigators.

Key Points

The aim was to determine if lowering serum cholesterol levels with clofibrate could reduce ischaemic heart disease incidence.
Conducted as a double-blind intervention trial starting in 1965.
Involved three European centers: Edinburgh, Budapest, and Prague.
Used clofibrate to lower serum cholesterol levels.
Reduction in ischaemic heart disease incidence with clofibrate was hypothesized, though specific data are not provided.
Clofibate was proposed based on its safety profile, aiming to avoid serious side effects.

Abstract

A co-operative trial in the primary prevention of ischaemic heart disease using clofibrate Report1 from the Committee of Principal Investigators SUMMARY A double-blind intervention trial was started in 1965 to test the hypothesis that the incidence of ischaemic heart disease in middle-aged men can be reduced by lowering raised serum cholesterol levels. It was carried out in 3 European centres-Edinburgh, Budapest, and Prague. Serum cholesterol was to be lowered by the drug clofibrate (ethyl chlorophenoxyisobutyrate) which was considered to be free from serious side effects.

问 AI

Bookmark

View Full Paper