Characteristics of successful and unsuccessful strategies to increase vaccine intention and improve vaccine uptake for U.S. adult populations in the Affordable Care Act era (2010-2025): a systematic review and meta-regression

July 10, 2026VaccineOpen Access

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Key Points

This research aims to summarize strategies to increase vaccine intention and uptake among U.S. adults from 2010 to 2025.
Conducted a systematic review and meta-regression of literature from 2010-2025.
Reviewed 92 studies, assessing quality using the EPHPP tool and certainty through GRADE.
Categorized strategies according to the WHO Behavioral and Social Drivers of Vaccination Model.
Higher vaccine uptake was linked to prioritizing specific populations (b=0.121, p=.027).
Service quality improvements and community-based recruitment showed significant increases in uptake rates (b=0.226, p=.040; b=0.585, p=.005).
Onsite vaccination during the COVID-19 pandemic was connected to lower uptake rates (b=-0.185, p=.033).

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Systematic review analyzes strategies to boost vaccine uptake in U.S. adults, suggesting multifactorial approaches can enhance effectiveness.

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Hensley et al. (2026) studied this question.

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