Two new chroman derivatives from the desert plant endophytic fungus Lasiodiplodia sp

Two previously undescribed chroman derivatives, designated as lasiodiones C (1) and D (2), were obtained from Lasiodiplodia sp., an endophytic fungus derived from desert plants surviving in unique biological environments. The chemical structures of these two compounds were unambiguously elucidated based on comprehensive spectroscopic data analyses. Their absolute configurations were further confirmed by comparing the experimental circular dichroism (CD) spectra with the electronic circular dichroism (ECD) spectra calculated via quantum chemical computations. Furthermore, the cytotoxic activities of compounds 1 and 2 were assessed against two human cancer cell lines, namely HGC-2 and A549. The results indicated that compound 2 possessed moderate cytotoxic effects, with IC50 values of 13.54 μM and 14.41 μM for HGC-2 and A549 cells, respectively.