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September 10, 2025Chemistry & Biodiversity

Dicymalides A–C: Three New Phthalide Derivatives From the Mangrove Endophytic Fungus Dicyma sp. L6B1

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Authors

XXXiao XiaoCZC. L. ZhangGXGao X

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Overview

New phthalide derivatives exhibit significant inhibitory activities in RAW264.7 cells, suggesting potential therapeutic applications.

Key Points

  • Three new phthalide derivatives were isolated from a mangrove endophytic fungus, showing potential anti-inflammatory properties.
  • Compound 8 demonstrated a potent inhibitory effect on nitric oxide production with a half-maximal inhibitory concentration of 1.0 µM.
  • The structure of the compounds was determined using high-resolution mass spectrometry and nuclear magnetic resonance data.
  • This research highlights the potential of endophytic fungi as a source for novel bioactive compounds.

Cite This Study

Xiao et al. (2025) studied this question.

synapsesocial.com/papers/68c1d7f654b1d3bfb60fa321https://doi.org/10.1002/cbdv.202502240
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