Dicymalides A–C: Three New Phthalide Derivatives From the Mangrove Endophytic Fungus Dicyma sp. L6B1

Three new phthalide derivatives, named dicymalides A–C ( 1–3 ), were isolated from the mangrove endophytic fungus Dicyma sp. L6B1, together with eight known compounds. The structures of these compounds were elucidated by high‐resolution electrospray ionization mass spectrometry, nuclear magnetic resonance spectroscopic data, single‐crystal X‐ray diffraction analysis, and specific rotation quantum‐chemical calculations. Inhibitory activities of 1–11 against nitric oxide production in lipopolysaccharide‐stimulated RAW264.7 cells were evaluated. Compound 8 exhibited potent inhibitory activity with a half‐maximal inhibitory concentration value of 1.0 µM.