Three Meroterpenes From the Mangrove Endophytic Fungus Phyllosticta sp. E2A1

Two new monoterpene‐shikimate‐conjugated meroterpenes, named phyllostictones J ( 1 ) and K ( 2 ), were isolated from the mangrove endophytic fungus Phyllosticta sp. E2A1, together with a new sesquiterpene‐shikimate‐conjugated spirocyclic meroterpene, named capitalensis E ( 3 ). The structures of 1–3 were elucidated by nuclear magnetic resonance spectroscopy (NMR), high‐resolution electrospray ionization mass spectrometry (HR‐ESI‐MS), single‐crystal x‐ray diffraction analysis, electronic circular dichroism (ECD) calculations, and modified Mosher's method. Compounds 1 – 3 were evaluated for their inhibitory effects on nitric oxide (NO) production in lipopolysaccharide (LPS)‐stimulated RAW264.7 cells. Among them, compound 2 exhibited inhibitory activity with an IC 50 value of 10.8 µM.