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July 13, 2026iScienceOpen Access

NLRP3 inflammasome partially mediates genotoxic E. coli infection in lean but not in genetically obese mice

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Authors

PFPauline FlochCGCécile GoursatLLLucas Lemmel

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Overview

Randomized trial investigates E. coli infection effects on inflammation in lean and obese mice, indicating differential responses based on metabolic state.

Key Points

  • The study aims to understand how E. coli infection affects gut microbiota and inflammation in lean and genetically obese mice.
  • Investigated the impact of genotoxic and proinflammatory E. coli strains on gut microbiota and inflammation in wild-type lean, ob/ob, and HFD-fed wild-type mice.
  • Monitored IL-18 levels and NLRP3 inflammasome activity to assess inflammation responses.
  • Analyzed alterations in gut microbiota and metabolic markers in each mouse group.
  • Only lean mice exhibited significant IL-18-associated colon inflammation due to genotoxic E. coli, influenced by NLRP3 inflammasome inhibition.
  • Ob/ob mice showed minimal gut microbiota changes in response to E. coli infection.
  • NLRP3 inflammasome partially mediates inflammation in lean mice during genotoxic E. coli infection, while having no effect in obese mice.

Cite This Study

Floch et al. (2026) studied this question.

synapsesocial.com/papers/6a547ff4475c38bf615a52eehttps://doi.org/10.1016/j.isci.2026.116674
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  5. 5Hyperglycemia worsens gut bacterial infection through intestinal Wnt, but independent of endotoxemia or obesity2025