Introduction Postoperative nausea and vomiting (PONV) are common adverse events following gynecological laparoscopic surgery. This study aims to evaluate the efficacy of transcutaneous auricular vagus nerve stimulation in reducing the incidence of PONV within 24 h after gynecological laparoscopic surgery.Methods and analysis This single-center, prospective, double-blinded, randomized and sham-controlled trial will enroll 200 patients scheduled for gynecological laparoscopic surgery. Participants will be randomized in a 1:1 ratio to either the taVNS group or the sham group. The taVNS group will receive electrical stimulation lasting for 30 min after anesthesia induction. Sham group will not provide stimulation. The primary endpoint is the incidence of PONV within the first 24 h after surgery. Secondary endpoints include the severity of PONV, the usage of rescue antiemetics and 5-point Likert satisfaction scale. Exploratory endpoints include consumption of opioids and heart rate variability within 24 h after surgery.Discussion The results of study will provide key evidence on the efficacy and safety of intraoperative taVNS for preventing PONV after gynecologic laparoscopic surgery.Trial registration: Chinese Clinical Trial Registry (registration No. ChiCTR2600120159; registered on March 10, 2026)
Li et al. (Sat,) studied this question.
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