ABSTRACT Precise monitoring and regulation of uric acid in synovial fluid is crucial for understanding uric acid‐related pathological environments. Here, we construct and evaluate a bifunctional Au@CeO 2 nanorod nanozyme platform that integrates ultrasensitive electrochemical sensing with photoelectrochemically driven uric acid degradation. The core–shell architecture couples plasmonic Au with catalytically active CeO 2 , facilitating detection of uric acid down to sub‐nanomolar levels and effective catalytic degradation via ROS ( * OH, * OO − , and 1 O 2 ). In situ Raman, EPR, and DFT studies provide insights into enhanced charge transfer and catalytic mechanisms at the heterointerface. Furthermore, the platform demonstrates coupled uric acid sensing and degradation performance in a simulated synovial fluid environment. Overall, this study provides a proof‐of‐concept demonstration of a nanozyme‐based electrochemical platform for integrated uric acid sensing and regulation under laboratory conditions and establishes a foundation for future investigations toward localized biofluid monitoring and modulation.
Liu et al. (Sat,) studied this question.