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July 13, 2026Autophagy ReportsOpen Access

Damage control: new functions for the Arp2/3 complex and WHAMM in autophagy and lysosomal homeostasis

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Authors

LWLianna H. WagnerKCKenneth G. Campellone

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Overview

Randomized trial demonstrates the impact of actin rearrangements on lysosomal health, indicating new intervention points.

Key Points

  • The aim is to clarify the roles of the Arp2/3 complex and WHAMM in autophagy, particularly regarding lysosomal function.
  • Examined the impact of Arp2/3 complex and WHAMM on autophagy and lysosomal integrity.
  • Analyzed actin cytoskeletal rearrangements at various stages of the autophagy process.
  • Arp2/3 complex plays a crucial role in the later stages of autophagy, enhancing lysosomal integrity.
  • WHAMM activates Arp2/3 at permeabilized lysosomes, impacting lysosomal damage responses.

Cite This Study

Wagner et al. (2026) studied this question.

synapsesocial.com/papers/6a548105475c38bf615a570fhttps://doi.org/10.1080/27694127.2026.2698348
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