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July 13, 2026Dementia and Geriatric Cognitive Disorders

Development and Validation of a Nomogram for Predicting Cognitive Impairment in Older Adults with Multimodal Sensory Impairments: A Study Based on NHANES

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Authors

SLShuangyue LiuSAShuangchun AiTDTirupapuliyur Damodaran

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Overview

Randomized trial develops a nomogram predicting cognitive impairment in older adults, suggesting improved early risk assessment.

Key Points

  • This study aimed to create a nomogram to evaluate the risk of cognitive impairment in older adults with sensory impairments.
  • Analyzed data from 2,897 participants aged ≥60 from NHANES (2011–2014).
  • Identified predictors using LASSO regression and multivariable logistic regression.
  • Evaluated model performance through AUC, calibration plots, and decision curve analysis.
  • Final nomogram included ten predictors like age, sex, race, and depression.
  • Achieved AUCs of 0.818 in training and 0.816 in validation cohorts (95% CI: 0.804-0.832 and 0.778-0.851, respectively).
  • Demonstrated significant clinical utility for early risk assessment based on calibration and decision curve analysis.

Cite This Study

Liu et al. (2026) studied this question.

synapsesocial.com/papers/6a548105475c38bf615a574ahttps://doi.org/10.1159/000552805
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