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July 13, 2026Molecular PsychiatryOpen Access

Neurobiological subtypes in alcohol use disorder and their phenotypic and clinical profiles

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Authors

LBLeyla R. BrucarEREric RawlsAZAnna Zilverstand

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Overview

Randomized trial reveals distinct neurobiological subtypes in alcohol use disorder, suggesting a new path for treatment personalization.

Key Points

  • This research aims to identify neurobiological subtypes in alcohol use disorder (AUD) and explore their clinical relevance.
  • Included 668 participants with resting-state fMRI data and clinical assessments from the Human Connectome Project.
  • Used a semi-supervised clustering approach based on graph theory metrics for subtype identification.
  • Validated subtypes through resampling, permutation testing, and assessed clinical relevance.
  • Identified two distinct neurobiological subtypes of AUD with unique clinical profiles.
  • Subtype 1 showed greater sensory-motor integration and externalizing behaviors; Subtype 2 demonstrated greater frontoparietal integration and internalizing behaviors.
  • Subtypes were robust across individuals with comorbid cannabis dependence, supporting generalizability.

Cite This Study

Brucar et al. (2026) studied this question.

synapsesocial.com/papers/6a548105475c38bf615a576dhttps://doi.org/10.1038/s41380-026-03748-4
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Bulk and Single-cell Transcriptomic Brain Data Identify Overlapping Processes and Cell-types with Human AUD and Mammalian Models of Alcohol Use2024
  2. 2Bulk and single-cell transcriptomic brain data identify overlapping processes and cell-types with human AUD and mammalian models of alcohol use2026 · 1 citations
  3. 3Differentiating Individuals with and without Alcohol Use Disorder Using Resting-State fMRI Functional Connectivity of Reward Network, Neuropsychological Performance, and Impulsivity Measures2022 · 16 citations
  4. 4Atypical effective connectivity from the frontal cortex to striatum in alcohol use disorder2024
  5. 5Integrative genomics approach identifies glial transcriptomic dysregulation and risk in the cortex of individuals with Alcohol Use Disorder2024 · 3 citations