What question did this study set out to answer?

The aim is to assess the effect of scFOS+ supplementation on gut microbiota and inflammation in aged mice.

July 13, 2026Scientific ReportsOpen Access

Prebiotic and postbiotic synergy alleviates age-related dysbiosis and inflammation in mice

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Randomized trial evaluates gut health improvement in aged mice using prebiotics and postbiotics, suggesting benefits for healthy aging.

The aim is to assess the effect of scFOS+ supplementation on gut microbiota and inflammation in aged mice.
18-month-old mice received 11% scFOS+ supplementation for 56 days.
Bodyweight and food intake were monitored; faecal and caecal samples were collected for microbiota analysis.
Cytokine production and toll-like receptor expression were analyzed at the study's conclusion.
scFOS+ supplementation decreased pathogenic bacteria and increased beneficial genera like Allobaculum and Bifidobacterium in aged mice.
The immune response in supplemented old mice aligned with adult patterns, reflected by TLR expression.
Overall, gut microbiota changes were linked to improved immune responses, supporting healthy aging.

Roméo et al. (2026) studied this question.

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