What question did this study set out to answer?

This research aims to find new inhibitors for RIPK3 to better manage atherosclerosis.

Identification of receptor-interacting protein kinase 3 inhibitor for atherosclerosis

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Randomized trial identifies new RIPK3 inhibitors in atherosclerosis, suggesting improved therapeutic options.

This research aims to find new inhibitors for RIPK3 to better manage atherosclerosis.
Utilized computational approach including virtual screening based on drug-likeness and pharmacokinetic properties.
Conducted docking studies to assess binding affinity of compounds.
Analyzed stability and reactivity of top compounds using density functional theory and molecular dynamics simulations.
Identified ZINC40012267 and ZINC96307758 as strong RIPK3 inhibitor candidates with better stability compared to GSK843.
Molecular dynamics simulations revealed favorable free energy landscape and low RMSD, RMSF values for top compounds.
Binding free energy validated through MMPBSA calculations.

Ngoruh et al. (2026) studied this question.

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