What question did this study set out to answer?

This research investigates how ENO2 promotes cancer stem cell properties and metastasis in triple-negative breast cancer (TNBC).

July 13, 2026Cell Death and DiseaseOpen Access

ENO2 sustains cancer stemness and metastatic competence through a phosphoenolpyruvate-dependent metabolic axis in triple-negative breast cancer

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Authors

CWCing-Hong WangNational Yang Ming Chiao Tung University RMRu-Tsun MaiNational Yang Ming Chiao Tung University KKKe Jia KhooNational Yang Ming Chiao Tung University

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Implication

Randomized trial reveals ENO2's role in sustaining cancer stemness and metastasis in triple-negative breast cancer, suggesting a new treatment target.

Key Points

This research investigates how ENO2 promotes cancer stem cell properties and metastasis in triple-negative breast cancer (TNBC).
Analyzed ENO2 expression in TNBC cohorts and its correlation with clinical outcomes.
Used genetic depletion and pharmacological inhibition of ENO2 to study effects on glycolysis, migration, and tumor growth.
Explored the role of phosphoenolpyruvate (PEP) and pyruvate in restoring CSC properties in ENO2-deficient cells.
Elevated ENO2 expression was linked to poor clinical outcomes in TNBC cohorts.
Genetic depletion of ENO2 resulted in reduced cancer stem cells and impaired tumor growth, illustrating its essential role.
Pharmacological inhibition of ENO2 with POMHEX mirrored genetic depletion effects, highlighting its potential as a therapeutic target.

Cite This Study

Wang et al. (2026) studied this question.

synapsesocial.com/papers/6a548195475c38bf615a5a12 https://doi.org/10.1038/s41419-026-09106-0

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Implication

Randomized trial reveals ENO2's role in sustaining cancer stemness and metastasis in triple-negative breast cancer, suggesting a new treatment target.

ENO2 sustains cancer stemness and metastatic competence through a phosphoenolpyruvate-dependent metabolic axis in triple-negative breast cancer

Discussion

Member takes

Implication

Key Points

Cite This Study

ENO2 sustains cancer stemness and metastatic competence through a phosphoenolpyruvate-dependent metabolic axis in triple-negative breast cancer

Discussion

Member takes

Implication

Key Points

Cite This Study

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