Key result
Pharmacological blockade of endothelin-1 reduces myocardial ischaemia/reperfusion injury in experimental animal models, though conflicting results exist depending on experimental conditions.
Population
Experimental animal models of myocardial ischaemia/reperfusion injury
Design
Review
Authors
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ET-1 modulation may attenuate ischemia-reperfusion injury in animals; leaves open translation to human MI therapy.
Endothelin-1 blockade demonstrates potential cardioprotective effects in experimental models of myocardial ischaemia and reperfusion, highlighting a possible therapeutic target.
Pernow et al. (1997) conducted a review in Myocardial ischaemia and reperfusion. Endothelin-1 blockade (monoclonal antibody, ECE inhibitor, or ET receptor antagonists) was evaluated on Myocardial ischaemia/reperfusion injury. Pharmacological blockade of endothelin-1 reduces myocardial ischaemia/reperfusion injury in experimental animal models, though conflicting results exist depending on experimental conditions.
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