Key result
Insulin-like growth factor I administered 1 hour prior to ischemia significantly attenuated myocardial injury compared to vehicle (P < 0.001) in a murine model.
Why the study?
Does insulin-like growth factor I (IGF-I) reduce myocardial injury in a murine model of myocardial ischemia reperfusion?
Does insulin-like growth factor I (IGF-I) reduce myocardial injury in a murine model of myocardial ischemia reperfusion?
p-value: p=< 0.001
IGF-I protects against myocardial ischemia-reperfusion injury in a murine model by inhibiting neutrophil-induced necrosis and myocyte apoptosis.
No takes yet. Share an insight, caveat, or question.
Preclinical IGF-I data merit human translation studies; leaves open any role in clinical ischemia-reperfusion injury.
Buerke et al. (1995) studied Myocardial ischemia reperfusion. Insulin-like growth factor I (IGF-I) vs. Vehicle was evaluated on Myocardial injury (creatine kinase loss) (p=< 0.001). Insulin-like growth factor I administered 1 hour prior to ischemia significantly attenuated myocardial injury compared to vehicle (P < 0.001) in a murine model.
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