Early Improvement in Left Ventricular Mechanics After Laparoscopic Sleeve Gastrectomy Detected by Global Longitudinal Strain

Q: What are the key findings of this study?

Laparoscopic sleeve gastrectomy significantly improved global longitudinal strain from -20.0% to -21.8% (p<0.001) at 3-6 months follow-up in patients with severe obesity.

Q: What is the clinical evidence from this study?

Study design: Observational. Population: Severe obesity (n=66). Intervention: Laparoscopic sleeve gastrectomy vs. Preoperative baseline. Primary outcome: Change in global longitudinal strain (GLS) (p=<0.001).

Q: What does this research mean for the field?

Laparoscopic sleeve gastrectomy is associated with significant early reductions in body weight, body mass index, and blood pressure at 3 to 6 months of follow-up. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

Q: What question did this study set out to answer?

To evaluate the early effects of laparoscopic sleeve gastrectomy on cardiac reverse remodeling and myocardial mechanics using conventional and speckle-tracking echocardiography.

Rabia Eker Akıllı; Ömer Tepe; Onur Sinan Deveci; Orçun Yalav; Ali Deniz; Haydar Ali Candan

doi:10.36516/jocass.1958178

June 30, 2026Cukurova Anestezi ve Cerrahi Bilimler DergisiOpen Access

Early Improvement in Left Ventricular Mechanics After Laparoscopic Sleeve Gastrectomy Detected by Global Longitudinal Strain

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Key result

Laparoscopic sleeve gastrectomy is associated with improved GLS from -20.0% to -21.8% in severe obesity.

P<0.001
n=66

Why the study?

Obesity causes structural and functional cardiac abnormalities, and this study aimed to evaluate the early effects of laparoscopic sleeve gastrectomy on cardiac remodeling and myocardial mechanics using speckle-tracking echocardiography.

Does laparoscopic sleeve gastrectomy improve global longitudinal strain and cardiac remodeling in patients with severe obesity?

Key Points

To evaluate the early effects of laparoscopic sleeve gastrectomy on cardiac reverse remodeling and myocardial mechanics using conventional and speckle-tracking echocardiography.
Retrospective single-center study evaluating N=66 patients with severe obesity undergoing laparoscopic sleeve gastrectomy.
Clinical, metabolic, and echocardiographic parameters were assessed preoperatively and at a mean follow-up of approximately 3-6 months (approximately 6 months in full text).
Left ventricular structure, diastolic function, and myocardial mechanics were quantified using conventional echocardiography and speckle-tracking global longitudinal strain.
Global longitudinal strain significantly improved from 20.0 ± 2.7% preoperatively to 21.8 ± 2.4% postoperatively (p<0.001), whereas left ventricular ejection fraction showed no significant change (70.1 ± 3.9% vs. 70.5 ± 3.3%, p=0.068).
Left ventricular mass regressed from 218.0 ± 42.0 g to 191.9 ± 49.1 g (p<0.001), and left atrial volume decreased from 50.3 ± 5.4 mL to 38.5 ± 4.5 mL (p<0.001).
Diastolic markers improved significantly, with the E/A ratio rising from 1.30 ± 0.20 to 1.59 ± 0.14 (p<0.001) and average E/e′ ratio decreasing from 6.94 ± 1.06 to 3.57 ± 0.33 (p<0.001).

Study Design

Type

Observational (n=66)

Multicenter

No

Structured PICO

Does laparoscopic sleeve gastrectomy improve global longitudinal strain and cardiac remodeling in patients with severe obesity?

P

Population

66 patients with severe obesity (mean age 36.9, 75.8% female) who underwent laparoscopic sleeve gastrectomy, followed for 3-6 months.

E

Exposure

Laparoscopic sleeve gastrectomy (LSG)

O

Outcome

Change in global longitudinal strain (GLS) values following laparoscopic sleeve gastrectomy during the early postoperative period despite preserved LVEFsurrogate

Main Result

Absolute Event Rate: -21.8% vs -20%

p-value: p=<0.001

Limitations

Single-center retrospective observational study with a relatively modest sample size
Follow-up duration was limited to the early postoperative period (3-6 months)
Absence of a non-surgical control group
Patients with overt heart failure and major systemic comorbidities were excluded
Advanced myocardial tissue characterization techniques, including cardiac magnetic resonance imaging, were not available
Exclusion of patients with overt heart failure and major systemic comorbidities

Implication

Laparoscopic sleeve gastrectomy in patients with severe obesity leads to early improvements in subclinical myocardial dysfunction as detected by global longitudinal strain, alongside reverse cardiac remodeling.

Abstract

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Discussion

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Cite This Study

Akıllı et al. (2026) conducted an observational in Severe obesity (n=66). Laparoscopic sleeve gastrectomy vs. Preoperative baseline was evaluated on Change in global longitudinal strain (GLS) (p=<0.001). Laparoscopic sleeve gastrectomy significantly improved global longitudinal strain from -20.0% to -21.8% (p<0.001) at 3-6 months follow-up in patients with severe obesity.

synapsesocial.com/papers/6a54a170da93060f8148c325 https://doi.org/10.36516/jocass.1958178

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Early Improvement in Left Ventricular Mechanics After Laparoscopic Sleeve Gastrectomy Detected by Global Longitudinal Strain

Key Points

Study Design

Structured PICO

Main Result

Limitations

Implication

Abstract

Discussion

Cite This Study

Early Improvement in Left Ventricular Mechanics After Laparoscopic Sleeve Gastrectomy Detected by Global Longitudinal Strain

Key Points

Study Design

Structured PICO

Main Result

Limitations

Implication

Abstract

Discussion

Cite This Study

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