Key result
KCNE1 beta-subunits interact with Kv7.1 alpha-subunits to form the native cardiac IKs channel, modifying channel gating and playing a crucial role in cardiac action potential repolarization.
This review provides a comprehensive overview of the molecular mechanisms by which KCNE1 interacts with and modulates the Kv7.1 channel, essential for cardiac repolarization.
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KCNE1-Kv7.1 interactions shape IKs repolarization; leaves open targeted modulation in inherited arrhythmias.
The classical tango is a dance characterized by a 2/4 or 4/4 rhythm in which the partners dance in a coordinated way, allowing dynamic contact. There is a surprising similarity between the tango and how KCNE β-subunits "dance" to the fast rhythm of the cell with their partners from the Kv channel family. The five KCNE β-subunits interact with several members of the Kv channels, thereby modifying channel gating via the interaction of their single transmembrane-spanning segment, the extracellular amino terminus, and/or the intracellular carboxy terminus with the Kv α-subunit. Best studied is the molecular basis of interactions between KCNE1 and Kv7.1, which, together, supposedly form the native cardiac I(Ks) channel. Here we review the current knowledge about functional and molecular interactions of KCNE1 with Kv7.1 and try to summarize and interpret the tango of the KCNEs.
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Wrobel et al. (2012) conducted a review in Cardiac arrhythmias (Long QT syndrome). KCNE1 and Kv7.1 interaction was evaluated. KCNE1 beta-subunits interact with Kv7.1 alpha-subunits to form the native cardiac IKs channel, modifying channel gating and playing a crucial role in cardiac action potential repolarization.
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