Key result
KCNQ1 forms channel complexes with all 5 KCNE subunits, but only interactions with KCNE1, KCNE2, and KCNE3 may have physiological relevance in the human heart based on expression and kinetics.
KCNQ1 interacts with all five KCNE subunits, but only KCNE1, KCNE2, and KCNE3 likely have physiological relevance in the human heart based on expression and electrophysiological properties.
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May guide targeted arrhythmia research on KCNQ1-KCNE1/2/3; leaves open KCNE4/5 roles pending human validation.
Bendahhou et al. (2005) studied KCNQ1/KCNE channel complexes in the human heart. Co-expression of KCNE subunits with KCNQ1 was evaluated on Electrophysiological properties and mRNA expression levels of KCNQ1/KCNE complexes. KCNQ1 forms channel complexes with all 5 KCNE subunits, but only interactions with KCNE1, KCNE2, and KCNE3 may have physiological relevance in the human heart based on expression and kinetics.
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