Population
COS-7 cells, KCNQ1-expressing oocytes, and adult guinea pig ventricular myocytes
Design
Preclinical
Authors
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Does not alter clinical arrhythmia management; leaves open KCNE2's role in human IKs regulation and disease.
KCNE2 can dynamically substitute for KCNE1 in the KCNQ1-KCNE1 complex, reducing cardiac IKs current amplitude.
Jiang et al. (2009) studied this question.
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