July 21, 2009PLoS ONEOpen Access

KCNE1 and KCNE3 β-Subunits Regulate Membrane Surface Expression of Kv12.2 K+ Channels In Vitro and Form a Tripartite Complex In Vivo

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Population

Xenopus oocytes and mouse brain membranes

Comparison

siRNA silencing or over-expression of KCNE1… vs Control (unmodified expression)

Design

Preclinical

Authors

Discussion

Oocyte findings suggest KCNE1/3 regulation of Kv12.2 currents; leaves open relevance to mammalian cardiac electrophysiology or arrhythmia mechanisms.

Population

Xenopus oocytes and mouse brain membranes

Intervention

siRNA silencing or over-expression of KCNE1 and/or KCNE3

Comparator

Control (unmodified expression)

Outcome

Macroscopic Kv12.2 currents and membrane surface expressionsurrogate

KCNE1 and KCNE3 interact directly with Kv12.2 channels to regulate channel membrane trafficking and function, forming a tripartite complex in vivo.

Clancy et al. (2009) studied this question.

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Oocyte findings suggest KCNE1/3 regulation of Kv12.2 currents; leaves open relevance to mammalian cardiac electrophysiology or arrhythmia mechanisms.