Key result
KCNE1 and KCNE3 accessory subunits radically alter the gating properties of the KCNQ1 potassium channel through interactions with the C-terminal domain and voltage sensing domain.
Population
KCNQ1 potassium channels and KCNE1/KCNE3 accessory subunits
Design
Preclinical
Authors
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Remains preclinical and should not guide therapy; extends molecular understanding of KCNQ1 regulation in animal models.
KCNE1 and KCNE3 homologous accessory peptides radically alter the gating properties of the KCNQ1 potassium channel via distinct mechanisms involving the voltage sensing domain and C-terminal motifs.
Jessica M. Rocheleau (2008) studied this question. KCNE1 and KCNE3 accessory subunits was evaluated on KCNQ1 channel gating properties and voltage sensor activation. KCNE1 and KCNE3 accessory subunits radically alter the gating properties of the KCNQ1 potassium channel through interactions with the C-terminal domain and voltage sensing domain.