Key result
KCNE1 slowed MTSET modification rates by approximately 10-fold without slowing voltage sensor equilibration, whereas KCNE3 shifted the voltage sensor equilibrium to favor the active state.
Population
Xenopus oocytes expressing KCNQ1 S4 cysteine mutants
Design
Preclinical
Authors
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Differentiates KCNE1/3 effects on KCNQ1 sensors in oocytes; extends channel biophysics while leaving cardiac IKs targeting unresolved.
KCNE1 and KCNE3 peptides differently modulate the voltage sensor in KCNQ1 K+ channels, demonstrating that the slow gating of the KCNQ1/KCNE1 complex is not due to slowly moving voltage sensors.
Rocheleau et al. (2007) studied this question. KCNE1 and KCNE3 peptides was evaluated on Voltage sensor equilibrium and equilibration rates (MTSET modification rates). KCNE1 slowed MTSET modification rates by approximately 10-fold without slowing voltage sensor equilibration, whereas KCNE3 shifted the voltage sensor equilibrium to favor the active state.
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