Key result
Transversal-axial tubule system (TATS) distribution governs the anatomical heterogeneity of calcium dynamics in atrial myocardium, with higher organization in the right atrial appendage.
Population
Mouse and human atrial myocardium
Reveals how region-specific organization of the transversal-axial tubule system influences calcium dynamics in the right atrium, suggesting implications for heart function.
Mouse and human atrial myocardium demonstrate high variability in the organization of the transversal-axial tubule system (TATS), with more organized TATS expressed in the right atrial appendage. TATS distribution governs anatomical heterogeneity of Ca 2+ dynamics and thus could contribute to integral atrial contractility, mechanics, and arrhythmogenicity.
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Lang et al. (2021) studied this question. Transversal-axial tubule system (TATS) distribution governs the anatomical heterogeneity of calcium dynamics in atrial myocardium, with higher organization in the right atrial appendage.
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