Key result
The presence of a sarcolemmal membrane at the cell periphery or in the TATS is required for the initiation of evoked Ca2+ transients and spontaneous Ca2+ sparks in rat atrial myocytes.
The presence of a sarcolemmal membrane either at the cell periphery or in the TATS in close apposition to the sarcoplasmic reticulum is required for the initiation of evoked Ca2+ transients and spontaneous Ca2+ sparks in rat atrial myocytes.
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No immediate clinical implications for atrial arrhythmias; hypothesis-generating for sarcolemmal roles in human Ca2+ signaling.
Kirk et al. (2003) studied Rat atrial myocytes (n=289). Presence of transverse-axial tubular system (TATS) vs. Cells without TATS was evaluated on Initiation of evoked Ca2+ transient and spontaneous Ca2+ sparks. The presence of a sarcolemmal membrane at the cell periphery or in the TATS is required for the initiation of evoked Ca2+ transients and spontaneous Ca2+ sparks in rat atrial myocytes.
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