Key result
Rat atrial myocytes display a predetermined spatiotemporal pattern of Ca2+ signaling during early excitation-contraction coupling, initiated by a consistent set of eager Ca2+ release sites.
Rat atrial myocytes exhibit a predetermined spatiotemporal pattern of calcium signaling during early excitation-contraction coupling, driven by specific 'eager' release sites.
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Fixed eager Ca2+ sites organize rat atrial E-C coupling; extends basic models but leaves open human translation.
MacKenzie et al. (2001) studied this question. Electrical excitation and Ca2+ manipulation was evaluated on Excitation-contraction coupling and Ca2+ signaling patterns. Rat atrial myocytes display a predetermined spatiotemporal pattern of Ca2+ signaling during early excitation-contraction coupling, initiated by a consistent set of eager Ca2+ release sites.
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