June 20, 2012

Gynecologic disorders and menstrual cycle lightheadedness in postural tachycardia syndrome

Q: What is the clinical evidence from this study?

Study design: Observational. Population: Postural tachycardia syndrome (n=160). Intervention: Postural tachycardia syndrome vs. Healthy controls. Primary outcome: Gynecologic history and lightheadedness during menstrual cycle phases.

KPKiffany PeggsVanderbilt University HNHoVan NguyenMeharry Medical College DEDiba EnayatVanderbilt University

Key Result

Patients with POTS reported increased lightheadedness through all menstrual cycle phases and a higher incidence of estrogen-related gynecologic diseases compared with healthy controls.

Study Design

Type

Observational (n=160)

Multicenter

Structured PICO

Does lightheadedness during menstrual cycle phases and incidence of gynecologic diseases differ between women with POTS and healthy controls?

Population

160 women, including 65 with postural tachycardia syndrome and 95 healthy controls, assessed via questionnaire for gynecologic history and menstrual cycle lightheadedness.

Comparator

Healthy control women (n=95)

Outcome

Differences in gynecologic history and lightheadedness during menstrual cycle phasespatient reported

POTS patients experience increased lightheadedness throughout the menstrual cycle, peaking during menses, and have a higher incidence of gynecologic diseases compared to healthy controls.

Abstract

OBJECTIVE: To assess differences in gynecologic history and lightheadedness during menstrual cycle phases among patients with POTS and healthy control women. METHODS: In a prospective, questionnaire-based study carried out at Paden Autonomic Dysfunction Center, Vanderbilt University, between April 2005 and January 2009, a custom-designed questionnaire was administered to patients with POTS (n=65) and healthy individuals (n=95). The results were analyzed via Fisher exact test and Mann-Whitney U test. RESULTS: Patients with POTS reported increased lightheadedness through all phases of the menstrual cycle phases as compared with healthy controls. Both groups experienced the greatest lightheadedness during menses, and a decrease in lightheadedness during the follicular phase. Patients with POTS reported a higher incidence of gynecologic diseases as compared with healthy controls. CONCLUSION: The severity of lightheadedness was found to vary during the menstrual cycle, which may relate to changes in estrogen levels. Patients with POTS also reported an increase in estrogen-related gynecologic disease.

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Cite This Study

Peggs et al. (Wed,) conducted a observational in Postural tachycardia syndrome (n=160). Postural tachycardia syndrome vs. Healthy controls was evaluated on Gynecologic history and lightheadedness during menstrual cycle phases. Patients with POTS reported increased lightheadedness through all menstrual cycle phases and a higher incidence of estrogen-related gynecologic diseases compared with healthy controls.

synapsesocial.com/papers/6a557efecae1d55e053ea8a4 https://doi.org/https://doi.org/10.1016/j.ijgo.2012.04.014

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