January 17, 2006Clinical ScienceOpen Access

Increased plasma angiotensin II in postural tachycardia syndrome (POTS) is related to reduced blood flow and blood volume

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Population

23 patients with postural tachycardia syndrome diagnosed by 70 degrees upright tilt, partitioned into low…

Design

Cross-sectional

Authors

JSJulian M. StewartNew York Medical College JGJ L GloverUniversity Hospitals Coventry and Warwickshire NHS Trust MMMarvin S. MedowNew York Medical College

Discussion

Member takes

Implication

Hypovolemia with elevated Ang II and suppressed renin in low-flow POTS is hypothesis-generating; prospective trials needed before any therapeutic targeting.

Structured PICO

Population

23 patients with postural tachycardia syndrome (POTS) diagnosed by 70 degrees upright tilt, partitioned into low blood flow (n=10), normal flow (n=8), and high flow (n=5), and 10 healthy volunteers.

Comparator

Healthy volunteers (n=10)

Outcome

Relationship between blood volume, Ang II, renin, aldosterone and peripheral blood flowsurrogate

Plasma Ang II is increased in low-flow POTS patients with hypovolemia, suggesting a role in local blood flow dysregulation and reduced NO bioavailability.

Cite This Study

Stewart et al. (2006) studied this question.

synapsesocial.com/papers/6a6ff3b4febe604dd708c4ab https://doi.org/10.1042/cs20050254

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Implication

Hypovolemia with elevated Ang II and suppressed renin in low-flow POTS is hypothesis-generating; prospective trials needed before any therapeutic targeting.

Increased plasma angiotensin II in postural tachycardia syndrome (POTS) is related to reduced blood flow and blood volume

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Increased plasma angiotensin II in postural tachycardia syndrome (POTS) is related to reduced blood flow and blood volume

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider