Why the study?
How does incremental upright tilt affect regional blood volume and flow in different subtypes of POTS compared to healthy volunteers?
Population
32 consecutive 14- to 22-yr-old patients with postural tachycardia syndrome comprising 13 with low-flow…
Comparison
Incremental upright tilt to 20 degrees, 35… vs Comparably aged healthy volunteers and supine…
Design
Cross-sectional
Authors
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Supports splanchnic vasoregulatory involvement in normal-flow POTS; hypothesis-generating and requires prospective validation before clinical consideration.
How does incremental upright tilt affect regional blood volume and flow in different subtypes of POTS compared to healthy volunteers?
Normal-flow POTS is characterized by selective orthostatic splanchnic vasodilation despite peripheral vasoconstriction, suggesting local splanchnic vasoregulatory factors contribute to the pathophysiology.
Stewart et al. (2005) studied this question.
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