April 12, 2007Clinical Journal of the American Society of Nephrology
Kidney Function, Electrocardiographic Findings, and Cardiovascular Events among Older Adults
Key result
Among older adults with CKD, each 10-ms increase in QRS interval was associated with a 15% greater risk for incident heart failure (HR 1.15; 95% CI 1.04-1.27).
Why the study?
Do resting electrocardiographic findings predict future cardiovascular events in older adults with chronic kidney disease?
Population
3,238 community-dwelling adults aged >=65 years. Key exclusions: prevalent heart disease, atrial…
Design
Cohort
Authors
Discussion
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Implication
May support ECG monitoring for risk stratification in older CKD adults; hypothesis-generating, needs prospective confirmation.
Study Design
Type
Cohort (n=3,238)
Structured PICO
Do resting electrocardiographic findings predict future cardiovascular events in older adults with chronic kidney disease?
P
Population
3,238 community-dwelling adults aged ≥65 years without prevalent heart disease, atrial fibrillation, pacemaker, or antiarrhythmic medication use.
E
Exposure
Resting electrocardiogram findings (QRS and QT intervals)
O
Outcome
Adjudicated incident heart failure (HF), incident coronary heart disease (CHD), and mortalityhard clinical
Main Result
Hazard Ratio: 1.15 (95% CI 1.04–1.27)
Resting electrocardiographic abnormalities independently predict future clinical cardiovascular events in older adults with chronic kidney disease.
Cite This Study
Kestenbaum et al. (2007) conducted a cohort in Chronic kidney disease (n=3,238). Resting electrocardiographic abnormalities (QRS and QTI intervals) vs. Normal electrocardiographic findings was evaluated on Incident heart failure (HR 1.15, 95% CI 1.04-1.27). Among older adults with CKD, each 10-ms increase in QRS interval was associated with a 15% greater risk for incident heart failure (HR 1.15; 95% CI 1.04-1.27).