Key result
Surgical inflammation and aging increase PND risk, while cognitive superagers show protective resilience.
Why the study?
Surgery and anesthesia act as extrinsic stressors that can challenge the aging brain, potentially disrupting memory and learning processes and contributing to the development of perioperative neurocognitive disorders.
Do surgery and anesthesia contribute to perioperative neurocognitive disorders in the aging brain?
Do surgery and anesthesia contribute to perioperative neurocognitive disorders in the aging brain?
Highlights the role of surgery and anesthesia as extrinsic stressors contributing to perioperative neurocognitive disorders in the aging brain.
May warrant heightened cognitive monitoring in elderly surgical patients; leaves open resilience mechanisms as prevention targets.
Aging is a progressive and inevitable process characterized by a persistent decline in functional capacity, driven by senescence mechanisms that affect all organ systems. This complex process is shaped by the interplay between intrinsic factors, such as systemic, cellular, and molecular changes, and extrinsic influences. Surgery and anesthesia act as extrinsic stressors that can challenge the aging brain, potentially disrupting memory and learning processes and contributing to the development of perioperative neurocognitive disorders (PND) [ 1 ].
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Thedim et al. (2025) conducted a review in Perioperative neurocognitive disorders (PND). Anesthesia and surgery was evaluated. Aging and surgery-induced inflammation increase the risk of perioperative neurocognitive disorders, while cognitive superagers exhibit resilience mechanisms that may protect against these outcomes.
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