Abstract Background and Objectives Iron deficiency without anaemia (IDWA) is a significant concern among blood donors. Reticulocyte haemoglobin content (RHC) has been increasingly investigated as an alternative biomarker to evaluate iron status, but its diagnostic performance remains unclear. We aim to assess the diagnostic accuracy of RHC for detecting iron deficiency in non‐anaemic blood donors. Materials and Methods PubMed, Embase, Scopus, Web of Science, Cochrane Library, ProQuest Dissertations the SROC AUC was 0.79 (95% CI: 0.71–0.85). The certainty of evidence was rated as very low to low. Conclusion Evidence from this review is insufficient to support the widespread use of RHC as a standalone screening test for IDWA in blood donors. Further studies are needed to improve RHC‐based screening strategies.
Yanyiam et al. (Sun,) studied this question.