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The study aimed to assess the diagnostic reliability of reticulocyte hemoglobin in identifying iron deficiency anemia and measuring early responses post iron infusion.

August 7, 2026CureusOpen Access

The Diagnostic Utility of Reticulocyte Hemoglobin in Iron Deficiency Anemia and Early Response Following Intravenous Iron Therapy

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The study aimed to assess the diagnostic reliability of reticulocyte hemoglobin in identifying iron deficiency anemia and measuring early responses post iron infusion.
Single-center observational design including case-control and longitudinal studies over 12 months.
Included 200 participants: 100 diagnosed with iron deficiency anemia and 100 healthy controls.
Measured RET-Hb and other parameters at baseline and 48 hours after intravenous iron therapy.
RET-Hb levels significantly lower in IDA patients (26.68 ± 4.04 pg) compared to controls (32.68 ± 1.94 pg; p < 0.001).
RET-Hb showed strong correlations with serum iron (r = 0.631), serum ferritin (r = 0.672), and TSAT (r = 0.619).
A RET-Hb cutoff of 29.65 pg predicted IDA with 73% sensitivity and 100% specificity (AUC = 0.895), with 80% of cases showing measurable improvement within 48 hours.

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Implication

Single-center observational trial evaluates reticulocyte hemoglobin's diagnostic utility in identifying iron deficiency anemia and early response to iron therapy.

Cite This Study

Meena et al. (2026) studied this question.

synapsesocial.com/papers/6a758c01847ab6d26c01fb1e https://doi.org/10.7759/cureus.113999

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Implication

Single-center observational trial evaluates reticulocyte hemoglobin's diagnostic utility in identifying iron deficiency anemia and early response to iron therapy.

The Diagnostic Utility of Reticulocyte Hemoglobin in Iron Deficiency Anemia and Early Response Following Intravenous Iron Therapy

Key Points

Discussion

Implication

Cite This Study

The Diagnostic Utility of Reticulocyte Hemoglobin in Iron Deficiency Anemia and Early Response Following Intravenous Iron Therapy

Key Points

Discussion

Implication

Cite This Study