The novel MYH7 mutation (p.T265I) was investigated for its pathogenicity in Chinese patients with familial hypertrophic cardiomyopathy, with TEM imaging revealing damaged mitochondria.
Observational
sample).Top image: Raw TEM image showing the overall morphology of the sample (scale bar: 1 μm); bottom image: Enlarged view of a typical region marked by the white box in the top image (scale bar: 0.5 μm), to clearly illustrate local structural details.The red arrows indicate damaged mitochondria.Statistical significance was determined by Student's t-test for all panels.Data were presented as mean ± standard error of the mean; * P < 0.05, ** P < 0.01, *** P < 0.001, and
Hao et al. (Wed,) conducted a observational in Familial hypertrophic cardiomyopathy. MYH7 mutation (p.T265I) was evaluated. The novel MYH7 mutation (p.T265I) was investigated for its pathogenicity in Chinese patients with familial hypertrophic cardiomyopathy, with TEM imaging revealing damaged mitochondria.