Key result
Older age, Caucasian ethnicity, female gender, and presence of arrhythmias were significantly associated with Takotsubo cardiomyopathy in liver transplant recipients (P=0.0001).
Why the study?
Takotsubo cardiomyopathy carries an adverse prognosis, and limited data suggest its occurrence in orthotopic liver transplant recipients is linked to elevated peri-operative risk.
Cohort
Yes
Older age, female gender, Caucasian ethnicity, and arrhythmias are significant predictors of developing Takotsubo cardiomyopathy following orthotopic liver transplantation.
May inform risk stratification for liver transplant recipients; leaves open causal inference and need for prospective validation.
BACKGROUND: Takotsubo cardiomyopathy (TCM), or stress-induced cardiomyopathy, is associated with adverse prognosis. Limited data suggest that TCM occurring in orthotopic liver transplant (OLT) recipients is associated with elevated peri-operative risk. AIM: To characterize the predictors of TCM in OLT recipients, using a large, multi-center pooled electronic health database. METHODS: A multi-institutional database (Explorys Inc, Cleveland, OH, USA), an aggregate of de-identified electronic health record data from 26 United States healthcare systems was surveyed. A cohort of patients with a Systematized Nomenclature of Medicine-Clinical Terms of "liver transplant" between 09/2015 and 09/2020 was identified. Subsequently, individuals who developed a new diagnosis of TCM following OLT were identified. Furthermore, the risk associations with TCM among this patient population were characterized using linear regression. RESULTS: 0.0001). CONCLUSION: non-recipients. Older age, Caucasian ethnicity, female gender, and presence of arrhythmias were significantly associated with TCM in LT recipients.
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Zmaili et al. (2022) conducted a cohort in Takotsubo cardiomyopathy in orthotopic liver transplant recipients. Older age, Caucasian ethnicity, female gender, and presence of arrhythmias was evaluated on Takotsubo cardiomyopathy (p=0.0001). Older age, Caucasian ethnicity, female gender, and presence of arrhythmias were significantly associated with Takotsubo cardiomyopathy in liver transplant recipients (P=0.0001).
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