Key result
Higher C-reactive protein to albumin ratio was significantly associated with long-term mortality after TAVI (median CAR 3.56 in non-survivors vs 1.13 in survivors, p<0.001).
Why the study?
Reliable and validated risk stratification tools for predicting mortality and allocating TAVI to adequate candidates are lacking, prompting evaluation of the C-reactive protein to albumin ratio as a prognostic marker.
Does the C-reactive protein to albumin ratio (CAR) predict long-term mortality in patients undergoing TAVI for symptomatic aortic stenosis?
Cohort (n=321)
Does the C-reactive protein to albumin ratio (CAR) predict long-term mortality in patients undergoing TAVI for symptomatic aortic stenosis?
p-value: p=< 0.001
The C-reactive protein to albumin ratio (CAR) is a significant independent predictor of long-term mortality in patients undergoing TAVI for symptomatic aortic stenosis.
Background Transcatheter aortic valve implantation (TAVI) is a less invasive and safe therapeutic alternative in patients who are at very high surgical risk or in whom there are contraindications to open surgery. On the other hand, allocating transcatheter therapy to the adequate candidates and identifying a reliable and validated risk stratification tool for mortality prediction is still lacking. The C-reactive (CRP) to albumin ratio (CAR) is a novel inflammation-based prognostic tool and it is strongly associated with inflammation severity and mortality. In this study, we aimed to elucidate the predictive significance of CAR for mortality in patients who underwent TAVI.Methods The records of 321 consecutive patients who underwent TAVI due to symptomatic aortic stenosis between 1 January 2015 and 31 December 2020 were analysed. Patients were divided into two groups based on the CAR values. For each group, all-cause, cardiovascular, and non-cardiovascular mortality occurring >72 h after the index procedure and at maximum follow-up was documented.Results The mean follow-up time was 40 (22–63) months. A total of 180 (56.1%) patients died during long-term follow-up. According to our study, median CAR values were significantly higher among patients who died during follow-ups compared to survivors [1.13 (0.69–2.21) vs 3.56 (1.53–10.00), p < 0.001].Conclusion Our data showed that CAR is an independent predictor of long-term mortality in patients undergoing TAVI due to symptomatic aortic stenosis.
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Avcı et al. (2022) conducted a cohort in Symptomatic aortic stenosis (n=321). C-reactive protein to albumin ratio (CAR) vs. Lower CAR values was evaluated on All-cause, cardiovascular, and non-cardiovascular mortality occurring >72 h after the index procedure (p=< 0.001). Higher C-reactive protein to albumin ratio was significantly associated with long-term mortality after TAVI (median CAR 3.56 in non-survivors vs 1.13 in survivors, p<0.001).
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