Key result
Aldosterone stimulates tissue inflammation, fibrosis, and remodeling through mineralocorticoid receptor activation, providing a mechanistic rationale for mineralocorticoid receptor antagonists.
Design
Review
Authors
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Supports MRA rationale in remodeling; leaves open prospective trials for inflammation-specific outcomes.
Mechanistic evidence of aldosterone-induced inflammation supports the therapeutic potential of mineralocorticoid receptor antagonists and aldosterone synthase inhibitors.
Gilbert et al. (2010) conducted a review in Aldosterone-induced tissue inflammation. Aldosterone was evaluated. Aldosterone stimulates tissue inflammation, fibrosis, and remodeling through mineralocorticoid receptor activation, providing a mechanistic rationale for mineralocorticoid receptor antagonists.
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