Key result
A history of methamphetamine dependence was associated with a significant reduction in heart rate variability, reduced parasympathetic activity, and diminished heartbeat complexity compared to controls.
Why the study?
Does a history of methamphetamine dependence reduce heart rate variability in currently abstinent individuals?
Case-Control (n=38)
Does a history of methamphetamine dependence reduce heart rate variability in currently abstinent individuals?
Chronic methamphetamine exposure is associated with persistent autonomic dysfunction, evidenced by decreased heart rate variability and impaired vagal function even during abstinence.
May warrant autonomic monitoring in methamphetamine users; hypothesis-generating for cardiovascular risk prediction.
Methamphetamine (METH) is an increasing popular and highly addictive stimulant associated with autonomic nervous system (ANS) dysfunction, cardiovascular pathology and neurotoxicity. Heart rate variability (HRV) has been used to assess autonomic function and predict mortality in cardiac disorders and drug intoxication, but has not been characterized in METH use. We recorded HRV in a sample of currently abstinent individuals with a history of METH dependence compared to age- and gender-matched drug-free comparison subjects. HRV was assessed using time domain, frequency domain, and non-linear entropic analyses in 17 previously METH-dependent and 21 drug-free comparison individuals during a 5 minute rest period. The METH-dependent group demonstrated significant reduction in HRV, reduced parasympathetic activity, and diminished heartbeat complexity relative to comparison participants. More recent METH use was associated with increased sympathetic tone. Chronic METH exposure may be associated with decreased HRV, impaired vagal function, and reduction in heart rate complexity as assessed by multiple methods of analysis. We discuss and review evidence that impaired HRV may be related to the cardiotoxic or neurotoxic effects of prolonged METH use.
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Henry et al. (2010) conducted a case-control in Methamphetamine dependence (n=38). Methamphetamine dependence vs. Drug-free comparison subjects was evaluated on Heart rate variability (HRV). A history of methamphetamine dependence was associated with a significant reduction in heart rate variability, reduced parasympathetic activity, and diminished heartbeat complexity compared to controls.
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