Key result
Muscle-specific expression of IGF-1 completely blocked angiotensin II-induced weight loss and skeletal muscle wasting in mice.
Why the study?
Does muscle-specific expression of IGF-1 prevent angiotensin II-induced skeletal muscle wasting in animal models?
Population
Mice (Wild-type and IGF-1-transgenic) infused with angiotensin II
Comparison
Muscle-specific expression of IGF-1 vs Wild-type mice infused with angiotensin II
Design
Preclinical
Authors
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IGF-1 may counter Ang II-driven muscle wasting; leaves open human translation and clinical testing.
Does muscle-specific expression of IGF-1 prevent angiotensin II-induced skeletal muscle wasting in animal models?
p-value: p=<0.01
Muscle-specific expression of IGF-1 prevents angiotensin II-induced skeletal muscle wasting by blocking apoptotic and proteolytic pathways, providing a potential therapeutic rationale for heart failure-associated cachexia.
Song et al. (2005) studied Angiotensin II-induced skeletal muscle wasting. Muscle-specific expression of IGF-1 (MLC/mIgf-1 transgene) vs. Wild-type (WT) mice was evaluated on Relative weight loss and reduction in muscle mass (p=<0.01). Muscle-specific expression of IGF-1 completely blocked angiotensin II-induced weight loss and skeletal muscle wasting in mice.
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