Key result
Early mechanical circulatory support and conservative defibrillation rescue refractory VF in sepsis-induced cardiomyopathy.
Why the study?
Sepsis-induced cardiomyopathy is rarely complicated by refractory ventricular fibrillation, which greatly increases mortality when it occurs.
Does early mechanical circulatory support combined with an appropriate frequency of defibrillation improve survival in sepsis-induced cardiomyopathy with refractory ventricular fibrillation?
Case Report (n=1)
No
Does early mechanical circulatory support combined with an appropriate frequency of defibrillation improve survival in sepsis-induced cardiomyopathy with refractory ventricular fibrillation?
Early implementation of mechanical circulatory support combined with limited defibrillation frequency may facilitate survival and recovery in patients with sepsis-induced cardiomyopathy and refractory ventricular fibrillation.
Hypothesis-generating for early mechanical support in sepsis-induced refractory VF; prospective trials needed before adoption.
Sepsis-induced cardiomyopathy (SIC) is generally characterized by decreased cardiac ejection fraction (EF) reversibility, less cardiac response to fluid resuscitation and catecholamine, and rarely complicated with refractory ventricular fibrillation (RVF). Once RVF is induced, the mortality rate of sepsis patients will be greatly increased. In this case, we reported a 26-year-old female patient who was diagnosed sepsis-induced cardiomyopathy (SIC), presented with RVF for 36 hours. The patient was maintained by the mechanical circulatory support (MCS) devices and experienced twice defibrillation. Finally, the patient was discharged without intracardial thrombosis and severe craniocerebral complications. This case suggested that early application of MCS and appropriate frequency of defibrillation may help the prognosis of SIC with RVF.
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Liu et al. (2024) conducted a case report in Sepsis-induced cardiomyopathy with refractory ventricular fibrillation (n=1). Mechanical circulatory support (VA-ECMO, IABP) and defibrillation was evaluated on Survival to discharge without severe craniocerebral complications. Early application of mechanical circulatory support and conservative defibrillation (2 shocks) successfully treated a 26-year-old female with sepsis-induced cardiomyopathy experiencing 36 hours of refractory ventricular fibrillation.
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