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July 15, 2026InflammopharmacologyOpen Access

Phytocompounds with immunomodulatory activities: mechanisms, therapeutic potential, and clinical prospects

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Authors

NMNoha A. MehanaNMNourhan Ibrahim MoradRMRehab Mekky

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Overview

This review shows phytocompounds modulate immune responses in various disorders, suggesting therapeutic potential in clinical settings.

Key Points

  • This review aims to synthesize information on phytocompounds with immunomodulatory activities and their therapeutic potential.
  • Conducted a structured literature search using databases like PubMed, Scopus, and Web of Science.
  • Analyzed major classes of bioactive phytocompounds including polysaccharides, flavonoids, and terpenoids.
  • Evaluated their effects on key immune cells and signaling pathways.
  • Phytocompounds showed capacity to modulate innate and adaptive immune responses.
  • Identified key signaling pathways such as NF-κB and JAK/STAT involved in immune modulation.
  • Highlighted challenges related to safety and the need for clinical validation in therapeutic applications.

Cite This Study

Mehana et al. (2026) studied this question.

synapsesocial.com/papers/6a57229088b21df87547f7b1https://doi.org/10.1007/s10787-026-02305-3
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