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July 15, 2026Clinical and Experimental OtorhinolaryngologyOpen Access

Context-Dependent Prognostic Impact of Microscopic Positive Surgical Margin in Papillary Thyroid Carcinoma

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Authors

HKHyungju KwonTKTing-Chun KuoMBMichael Bouvet

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Overview

Retrospective study explores recurrence risk associated with microscopic positive surgical margins in papillary thyroid carcinoma, indicating clinical relevance in node-negative patients.

Key Points

  • This study investigates how microscopic positive surgical margins (mPSMs) influence recurrence risk in papillary thyroid carcinoma (PTC) in context to nodal status.
  • Retrospective analysis of 2,539 patients who underwent thyroidectomy for PTC from 2009 to 2023.
  • Patients were categorized by nodal status (N0, N1a, N1b) and analyzed using Cox proportional hazards modeling, survival tree analysis, and random survival forest analysis.
  • The primary outcome measured was recurrence-free survival (RFS).
  • mPSM was observed in 2.9% of N0 patients, 4.7% of N1a patients, and 8.6% of N1b patients.
  • In N0 patients, mPSM significantly reduced 5-year RFS (90.2% vs. 99.1%, p = 0.002; HR 5.513, 95% CI 1.657-18.35).
  • No significant association between mPSM and recurrence was found in the N1a (HR 0.960, 95% CI 0.130-7.077) or N1b (HR 1.466, 95% CI 0.337-6.379) groups.

Cite This Study

Kwon et al. (2026) studied this question.

synapsesocial.com/papers/6a5722be88b21df87547fab4https://doi.org/10.21053/ceo.2026-00029
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Prognostic Significance of Microscopic Positive Margin in Differentiated Thyroid Carcinoma: A Systematic Review and Meta-Analysis2026
  2. 2Prognostic Factors and Recurrence in Papillary Thyroid Microcarcinoma2026
  3. 3Analysis of Risk Factors for High-Risk Lymph Node Metastasis in Papillary Thyroid Microcarcinoma2025 · 1 citations
  4. 4Clinicopathological Evaluation of Papillary Thyroid Microcarcinoma2024 · 1 citations
  5. 5The Prognostic Impact of the Surgical Margin in Renal Cell Carcinoma Treated with Partial Nephrectomy: A Multi-Center Study2024 · 5 citations