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July 15, 2026EndocrineOpen Access

Genetic determinants of obesity: mechanisms, clinical implications, and targeted therapies

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Authors

ASAnastasios SerbisEKEvanthia KantzaMGMichaela Garoufou

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Overview

This review examines genetic factors influencing obesity, highlighting clinical implications and treatment opportunities.

Key Points

  • The aim is to understand genetic contributors to obesity for better diagnosis and management.
  • Utilized genome-wide association studies (GWAS) and sequencing technologies to analyze genetic alterations.
  • Discussed various forms of obesity: polygenic, syndromic, and monogenic.
  • Synthesized recent findings on genetic basis and its clinical implications.
  • Polygenic obesity involves a complex interplay between genetic susceptibility and environmental factors.
  • Syndromic obesity is characterized by early-onset with additional developmental and physical traits.
  • Monogenic obesity, though rare, reveals key appetite regulation pathways linked to the hypothalamus.

Cite This Study

Serbis et al. (2026) studied this question.

synapsesocial.com/papers/6a5722f088b21df87547fc54https://doi.org/10.1007/s12020-026-04696-3
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