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The research aims to understand the epigenetic and transcriptional differences during human B cell maturation and bifurcation.

July 15, 2026Nature CommunicationsOpen Access

Epigenetic signatures mark early peripheral human B lineage bifurcation and differential transcriptional profiles in mature populations

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Randomized trial reveals epigenetic signatures and transcriptional profiles in B cell maturation, suggesting key developmental insights.

The research aims to understand the epigenetic and transcriptional differences during human B cell maturation and bifurcation.
Isolated T1, T2M hi, and T2M lo B cells from human adult and cord blood.
Utilized bulk and single-cell ATAC-seq, RNA-seq, CUT&RUN, and CITE-seq for profiling.
Employed imaging mass cytometry with RNAscope to validate gene expression and spatial relationships.
Identified distinct accessible chromatin domains separating T2M hi and T2M lo B cells.
Epigenetic signatures persisted during T2M lo differentiation to naïve B cells.
Memory and marginal zone B cells maintained epigenetic hallmarks of their precursors, highlighting transcriptional diversity.

Dionisi et al. (2026) studied this question.

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