Randomized trial assesses collagen's role in histological grading and survival in breast cancer, suggesting its prognostic significance.
Key Points
The study investigates the correlation between intratumoral collagen deposition and histological grade, aiming to improve prognostic assessments in breast cancer.
Used Masson Trichrome staining for collagen assessment in tumor slides (n=166).
Conducted proteomic and transcriptomic analyses across METABRIC (n=1827) and TCGA-BRCA (n=753) datasets.
Evaluated the relationship between collagen levels and histological grade in breast cancer tumors.