Reading the Genome as a Biological Specification: A Hypothesis of Genome-Scale Biological Interpretation

The human genome contains far more information than protein-coding sequences alone. Contemporary genomics has identified genes, regulatory elements, chromatin organisation, transcriptional networks, non-coding RNAs, and numerous conserved functional regions, yet these are typically represented as independent annotation layers rather than as components of a unified biological specification. This paper advances the hypothesis that genomic information can be interpreted as a coherent biological specification extending from molecular production to developmental organisation and phenotype. The paper argues that chromosome-scale interpretation may be possible without requiring prior disclosure of a complete decoding methodology. Instead, it establishes the conceptual foundations for treating genomic information as a structured biological document whose interpretation is constrained by experimentally observable genomic, developmental, and physiological evidence. The work distinguishes clearly between established biological knowledge and proposed theoretical constructs, identifies empirical criteria by which the hypothesis may be evaluated, and outlines falsifiable predictions that future comparative genomic and developmental studies may test. No claim is made that a complete genome-scale interpreter presently exists; rather, the paper proposes that such an interpretation represents a scientifically testable research programme.